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Login in the system, enter DLEPS page

Enter the sub system

Subsystem

Upload files

Three input files:
In the chemical info file，SMILES column is obligated，others are optional

Up / down gene signatures:

On this site, make a conversion
https://biit.cs.ut.ee/gprofiler/convert

File example, only gene digital ID (ENTREZGENE_ACC) one line each

Down gene signatures can be omitted

You can also use the built-in fda961 and np2720 libraries

Return to the result page after submission,
the calculation results can be downloaded,and a negative score means that up/down gene signatures can be reversed

If only up genes are entered, a positive score means up genes can be activated