GigaCeuticals

Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning Nature biotechnology 2021 (IF=36.6)

Authors： Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou,*, Ning Zhang*, Ruimao Zheng*, Zhengwei Xie*

Date: June 17, 2021

Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis

Authors：Yiming Wang, Weikaixin Kong, Liang Wang, Tianyu Zhang, Boyue Huang, Jia Meng, Baoxue Yang, Zhengwei Xie*, Hong Zhou*

Date: October 18, 2020

Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing

Authors：Weikaixin Kong#, Xinyu Tu#, Weiran Huang, Yang Yang, Zhengwei Xie*, Zhuo Huang*

Date: May 18, 2020

Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines

Authors：Boyue Huang, Dandan Zhong, Jie Zhu, Yongpan An, Miaomiao Gao, Shuai Zhu, Weiwei Dang, Xin Wang, Baoxue Yang*, Zhengwei Xie*

Date: March 11, 2020

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression

Authors：Yao Dang, Yongpan An, Jinzhao He, Boyue Huang, Jie Zhu, Miaomiao Gao, Shun Zhang, Xin Wang, Baoxue Yang*, Zhengwei Xie*

Date: November 26, 2019

Genome-scale fluxes predicted under the guidance of enzyme abundance using a novel hyper-cube shrink algorithm

Authors：Zhengwei Xie*, Tianyu Zhang, Qi Ouyang*